http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3220956-A1

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filingDate 2015-10-08-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_03e88154f9b26d4e331f0dfbdf6a4192
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f02fa2c8438b28e05ea1fe750d1c0649
publicationDate 2017-09-27-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber EP-3220956-A1
titleOfInvention Conjugates and conjugating reagents
abstract The invention relates to a conjugate of a protein or peptide with a therapeutic, diagnostic or labelling agent, said conjugate containing a protein or peptide bonding portion and a polyethylene glycol portion; in which said protein or peptide bonding portion has the general formula: in which Pr represents said protein or peptide, each Nu represents a nucleophile present in or attached to the protein or peptide, each of A and B independently represents a C1-4alkylene or alkenylene chain, and W represents an electron withdrawing group or a group obtained by reduction of an electron withdrawing group; and in which said polyethylene glycol portion is or includes a pendant polyethylene glycol chain which has a terminal end group of formula -CH2CH2OR in which R represents a hydrogen atom, an alkyl group, or an optionally substituted aryl group. Also claimed are a method for making such a conjugate, and novel reagents useful in that method.
priorityDate 2014-10-24-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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