| abstract |
The present invention relates to a composition for use in a method for inducing an immune response in a mammalian subject in need thereof comprising an effective amount of at least 107 infectious units (ifu) of E1 and E3 deleted adenovirus encoding an antigen selected from an influenza antigen, a HBV antigen, a HBV surface antigen, a HPV antigen, a HCV antigen, an anthrax protective antigen or anthrax lethal factor antigen, wherein the composition is intranasally administered and the immune response is elicited within twenty-four hours of administration. |