| abstract |
The invention concerns a combination comprising at least one 2-oxo-indole derivative of formula (I) in which R 1 is selected from the group consisting of thienyl, imidazolyl and pyridyl, optionally substituted by (C 1 -C 3 ) alkyl, A is a -CH 2 CO- o -SO 2 - group; R is selected from the group consisting of 6,7-dimethoxy-1,2,3,4- tetrahydroisoquinolinyl, 3,4-dimethoxy-benzylamino, (C 1 -C 3 )alkyl, benzyl or a pharmaceutically acceptable salt thereof and at least one antitumor drug. The combination is for use in the treatment of tumors, in particular glioblastoma multiforme (GBM), breast tumor and pancreatic tumor. The combination is effective in the treatment of resistant tumor forms. |