| abstract |
A compound comprising at least one looped peptide structure attached via at least two sulfone linkages formed through cysteine residues of the peptide to a scaffold, wherein the looped peptide comprises an amino acid sequence of formula (I): n n -C i -X-U/O-X-X-G-C ii -E-D-F-Y-X-X-C iii - (SEQ ID NO: 1) (I) n nor a modified derivative, or pharmaceutically acceptable salt, thereof; nwherein: nC i , C ii and C iii represent first, second and third cysteine residues, respectively; nX represents any amino acid residue; nU represents a polar, uncharged amino acid residue selected from N, C, Q, M, S and T; and nO represents a non-polar aliphatic amino acid residue selected from G, A, I, L, P and V. n Preferably, the compound is a bicyclic peptide having two peptide loops between three sulfone linkages to the scaffold. |