| abstract |
An antibiotic polymethyl methacrylate bone cement is proposed, which is composed of methyl methacrylate, at least one polymethyl methacrylate or a polymethyl methacrylate copolymer, at least one polymerization initiator, such as a free-radical initiator, at least one polymerization accelerator and at least one X-ray opacifier, wherein the components in a powdery component and a liquid monomer component or in two at room temperature paste-like components. The polymethyl methacrylate bone cement according to the invention comprises the cyclic lipopeptide daptomycin a pharmacologically acceptable salt of daptomycin, a solvate and / or a hydrate containing daptomycin and at least one calcium salt which preferably has at least two different release profiles. |