http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3177921-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0db512e83dae84e314ce83ca01509424 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_853249c166c80fa802fecbf69fcac430 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9eceb838946038f18d39f95106fdcdf6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0a1e5636829b65f8ca585878a7351f39 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-75 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2800-226 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2800-224 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-7454 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2800-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2201-12 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-4905 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N21-31 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-49 |
| filingDate | 2015-07-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_093e443181ee9714d67bbf0b6b8366ca http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cace5b2a09c694f6e8af1f493429c650 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e0fbcc1ffc62eeadd8c59d56e3d545e1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2285ffd3190ef75b1d50ded06bfce78c |
| publicationDate | 2017-06-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-3177921-A1 |
| titleOfInvention | Method for determining the structural profile of a fibrin clot reflecting the stability thereof, in order to predict the risk of bleeding, thrombosis or rethrombosis |
| abstract | The present invention relates to a method for dynamically determining the structural profile of a fibrin clot, reflecting the stability thereof in a biological sample of a patient, said method comprising the following steps: a) mixing the undiluted biological sample with tissue factor or a mixture of tissue factor and tissue plasminogen activator; b) incubating the mixture obtained in step a), then adding calcium ions to the mixture obtained, in order to initiate the formation of a fibrin clot; c) measuring the turbidity or the optical density of the clot being formed in step b), at at least two wavelengths of between 450 nm and 850 nm, and for a time of between 1 and 35 minutes; d) determining the structural profile of the analysed clot, expressed as a number of protofibrils, density and radius in c) by means of the formula τ.λ5 = A [Fg].(λ2 - B), wherein τ is the turbidity of the clot at a given wavelength λ, [Fg] is the initial weight concentration of fibrinogen, and A and B are coefficients which are proportional, respectively, to the density and the radius of the fibres that make up the clot; and e) comparing the obtained profile with a control. The method preferably includes a step f) that makes it possible to predict the risk of bleeding, thrombosis or rethrombosis and to select the anticoagulant that is best suited to the clinical situation of a patient. |
| priorityDate | 2014-07-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 158.