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publicationDate 2017-05-31-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber EP-3173782-A1
titleOfInvention Method for controlling continuous chromatography and multi-column chromatography assembly
abstract In summary, the invention relates to a method for controlling at least one multi-column chromatography arrangement for the continuous process of purifying in particular biopharmaceuticals, comprising: - introducing a first multicomponent mixture into a column of the multicolumn chromatography arrangement; - Detecting at least one multivariate signal by means of at least one detector; Calculating at least one process parameter based on the multivariate signal by means of at least one data processing program of a computing unit by using a chemometric method; Controlling the purification process by controlling at least one controllable control element on the basis of the at least one process parameter, as well as a multi-column chromatography arrangement.
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