| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8b0395805ee2352a18a9d72ac99ab524
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_400b987bbcbec8b47c3037cb7865a70e |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2320-31
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2800-52
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-141
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2710-24132
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-916
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-4703 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-57488
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-57426
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-1135
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K35-76
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K35-763 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-574 |
| filingDate |
2015-11-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a5a9d55c7d04db61f651de145e0000ad
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fa7c3a2f12dd27c1e32e4861298c9a26
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_085ae5d6bc982939993bd9e9e04fb7f1
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_703194b5aa4dde81606fe1bb375b4f66
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8c71daaac1ff194d3a5a4bebb9c3b223
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_565d2bbc3990f54b7f9fc03bbe346153
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a76f4e5803eed26bc3228679444fe40d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a76fe2a7c956e8c603136d665618f12b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3cc937601ec3fab5b5fe7cb6c246bfe4 |
| publicationDate |
2017-05-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-3163302-A1 |
| titleOfInvention |
Samhd1 modulation for treating resistance to cancer therapy |
| abstract |
The present invention pertains to novel treatments for cancer diseases. Treatment of cancers with nucleoside analogs (NA), which specifically inhibit rapidly dividing cells, may face preexisting NA resistance or development of resistant cancer cells resulting in poor clinical prognosis. Treatment of cancers with oncolytic herpes simplex viruses (HSV) may face preexisting resistance or development of resistant cancer cells resulting in poor clinical prognosis. The invention overcomes chemotherapy resistance or resistance to oncolytic HSV by providing methods for detecting the resistance in a cancer disease based on the expression of SAM domain and HD domain-containing protein 1 (SAMHD1) in cancer cells. Furthermore provided are treatment options addressing the chemotherapy resistance such as a combination of a SAMHD1 inhibitor with a NA. Moreover, provided are treatment options addressing the resistance to oncolytic HSV such as a combination of a SAMHD1 inhibitor or depletion of SAMHD1 with an oncolytic HSV. The invention provides new medicines and companion diagnostics supporting clinical treatment decisions. |
| priorityDate |
2015-11-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |