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filingDate 2015-06-29-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4aff298adb54f87d4d7adca8ef54dab4
publicationDate 2017-05-03-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber EP-3161141-A1
titleOfInvention Transgenic plants expressing a tetravalent chimeric dengue virus antigen to produce effective vaccines derived therefrom
abstract The present invention generally relates to the field of plant molecular biology and biotechnology as it applies to the production of plant-derived vaccines. More particularly, the present invention pertains to recombinant DNA molecules encoding a chimeric tetravalent dengue virus antigen, and vectors, transgenic plastids, transgenic plant cells, transgenic plants and transgenic parts of such plants comprising said recombinant DNA molecules as well as useful for preparing genetically transformed plant and plant cells. The invention includes plant optimized genes that encode chimeric tetravalent dengue virus antigen. The chimeric tetravalent dengue virus antigen is preferably a polyprotein comprising the immunoglobulin-like domain of the envelope protein of the dengue virus serotype-1, the immunoglobulin-like domain of the envelope protein of the dengue virus serotype-2, the immunoglobulin-like domain of the envelope protein of the dengue virus serotype-3 and the immunoglobulin-like domain of the envelope protein of the dengue virus serotype-4. The transgenic plastids, transgenic plant cells, transgenic plants and transgenic parts of such plants are preferably of the Asteraceae family.
priorityDate 2014-06-27-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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