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filingDate 2015-06-18-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a4b5d83240eb44dad5d723e3f7c7a050
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publicationDate 2017-04-26-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber EP-3157958-A1
titleOfInvention Car-expressing nk-92 cells as cell therapeutic agents
abstract The present invention relates to an ErbB2-specific NK-92 cell or cell line containing a lentiviral vector encoding a chimeric antigen receptor and preferably two vector integration loci in its cellular genome. The present invention further relates to the use of the ErbB2-specific NK-92 cell or cell line in the prevention and/or treatment of cancer, preferably ErbB2-expressing cancers. The present invention further relates to the use of the ErbB2-specific NK-92 cell or cell line as targeted cell therapeutic agent and/or for adoptive cancer immunotherapy. The present invention further relates to a method for generating an ErbB2- specific NK-92 cell or cell line as well as to a method for identifying an ErbB2-specific NK-92 cell or cell line and to the ErbB2-specific NK-92 cell or cell line obtained or identified by the methods as well as their uses.
priorityDate 2014-06-18-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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