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filingDate 2015-04-10-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bf5446e58343efaf41bab103a2fbbd24
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publicationDate 2017-02-15-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber EP-3129504-A2
titleOfInvention Use of micro-ribonucleic acid (mirna) to diagnose transplant rejection and tolerance of immunosuppression therapy
abstract The present invention relates to the discovery that the expression levels of some microRNAs (miRNAs) can use a diagnostic signature to predict transplant outcomes in a transplant recipient. Thus, in various embodiments described herein, the methods of the invention relate to methods of diagnosing a transplant subject for acute rejection such as acute cellular rejection (ACR), methods of predicting a subject's risk of having or developing ACR and methods of assessing in a subject the likelihood of a successful or failure minimization of immunosuppression therapy (IST) dosage from standard ranges.
priorityDate 2014-04-10-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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