http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3121292-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9be598030308ba9c3de373cbf98c6dcf |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6841 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68 |
| filingDate | 2009-11-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fa6942a7b2f8469890aab51812bacd4e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_058446b9ae80eec43f7a7b77e497ac67 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3e570f556542d92d8260a7a6dc4655cf http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_407e8c2134f0e5243609e112ff284c9e |
| publicationDate | 2017-01-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-3121292-A1 |
| titleOfInvention | Automated method for detecting cancers and high grade hyperplasias |
| abstract | An automated method of screening for cervical cancer cells, comprising the steps of: n(a) obtaining a slide containing a fluid biological sample comprising nuclei from a subject, said biological sample having been contacted with a first nuclear centromeric probe bearing a first detectable label directed either to chromosome 3 or chromosome 7, and a second nuclear non-centromeric probe bearing a second detectable label directed to single copy sequences on the q arm of chromosome 3 wherein said single copy sequences comprise a contiguous sequence of four overlapping BAC clones containing at least a portion of the TERC gene at chromosomal location 3q26, and counterstained with DAPI, wherein said first and second probes are contacted under conditions that promote hybridization of each said first and second probe to the respective chromosomal loci; n(b) searching said slide for DAPI stained areas within said biological sample; n(c) searching said DAPI stained areas for the presence of label of said first nuclear centromeric probe and label of said second nuclear non-centromeric probe; n(d) quantitatively determining the number of said first nuclear centromeric probe and second nuclear non-centromeric probe per nucleus in each DAPI stained area within said biological sample; n(e) designating the biological sample as comprising a potential for progression to high hyperplasia and invasive cervical cancer when the number of said first probe per nucleus within the DAPI is about 2 per nucleus and the number of said second nuclear non-centromeric probe per nucleus within the DAPI stained area is equal to or greater than 4. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11060134-B2 |
| priorityDate | 2009-03-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 103.