http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3115358-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_523409f720145382e5e117548ae6ae76 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D211-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B53-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D211-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07B53-00 |
| filingDate | 2014-03-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3345d736de8f4d8ab2727b845db25746 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_39a14c7f1d213f1814234144f5848e14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5964ed980799a9ba2fdb215fd1c8b2d4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_238bec32f307986e3751c22847b11b3b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_30df5fe36b89ee4983ab97a7ea9bcd45 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_501318d2cb9cbfa308714f8858f4a1e2 |
| publicationDate | 2017-01-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-3115358-A1 |
| titleOfInvention | Method of preparation and chiral inversion of chiral-1-t-butoxycarbonyl-3-hydroxy piperidine |
| abstract | The present invention relates to a method of preparation and chiral inversion of chiral-1-t-butoxycarbonyl-3-hydroxy piperidine, the method mainly comprising the steps of: using N-benzyl-3-hydroxy piperidine as raw material, and splitting to obtain (S) or (R)-1-benzyl-3-hydroxy piperidine camsylate; dissociating by a base to obtain (S) or (R)-1-benzyl-3-hydroxy piperidine; conducting hydrogenating debenzylation/t-butoxycarbonyl protection by palladium-charcoal to obtain (S) or (R)-1-t-butoxycarbonyl-3-hydroxy piperidine. Using (R) or (S)-1-substituted-3-hydroxy piperidine as raw material, and acylating the substituted sulfonyl chloride to obtain (R) or (S)-1-substituted-3-hydroxy piperidine sulfonic ester; substituting in substitute carboxylates to obtain (S) or (R)-1-substituted-3-hydroxy piperidine carboxylic ester; hydrolyzing by base to obtain (S) or (R)-1-substituted-3-hydroxy piperidine. The synthesis route has mild reaction conditions, and is suitable for industrial mass production. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113461598-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3170809-A4 |
| priorityDate | 2014-03-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 52.