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publicationDate 2016-12-07-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber EP-3101426-A2
titleOfInvention Alpha2-macroglobulin from cerebrospinal fluid as an index marker for neuromyelitis optica
abstract The purpose of the present invention is to develop: a method for selectively separating a glycoprotein derived from the central nervous system from a body fluid or a central nervous system cell; and a method for searching for an index marker for central nervous system diseases, which utilizes the aforementioned method. A protein derived from the central nervous system, which occurs in a trace amount in a body fluid or a central nervous system cell, can be selectively enriched by a two-stage separation procedure comprising removing a glycoprotein having sialic acid at a non-reducing terminal thereof from the body fluid or the central nervous system cell and then separating a glycoprotein having N-acetylglucosamine at a non-reducing terminal thereof.
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