| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1721d75f5bf603447ec5a26b5c1c0be0 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-88
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-91 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-517
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-91
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-88 |
| filingDate |
2015-01-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e8bdb6f750c2825446a99edaaa185033
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7b4c3c7996bbd97e205cbb80fb988a5b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8e3be4ea015f4c205917c0758f7fa8fe |
| publicationDate |
2016-11-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-3094332-A1 |
| titleOfInvention |
Carbonyl erastin analogs and their use |
| abstract |
The present invention provides, inter alia, compounds having the structure of formula (I): Compositions containing such compounds are also provided. Methods for using such compounds or compositions for treating or ameliorating the effects of a cancer having a cell that harbors an oncogenic RAS mutation, for modulating a lipoxygenase in a ferroptosis cell death pathway, and for depleting reduced glutathione (GSH) in a cell harboring an oncogenic RAS mutation are further provided. |
| priorityDate |
2014-01-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |