| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2efbe95965e682e179dfd266c9980505 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J31-0215
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J31-0211
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J27-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J31-0257
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D493-04 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-424
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D493-04 |
| filingDate |
2014-12-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a97cd125d66d0a0bf573f1a8592a06b4
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_64bcd6279bc024f6fb8feec6217bd642
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a4c57e1bda028fc1f1b8b7d990b7790f |
| publicationDate |
2016-10-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-3083636-A1 |
| titleOfInvention |
Enhanced regio-selectivity in glycol acylation |
| abstract |
A method for acid-catalyzed acylation of an isohexide is described. The method involves a reaction of an isohexide and an excess of carboxylic acid in the presence of a Lewis acid or a Brnsted acid catalyst. One or more Lewis acid or Brnsted acid can faciliate conversion of isohexides to their corresponding mono and diesters with a pronounced greater regio-selectivity of exo-OH over endo-OH of the isohexide in the product. Particular catalytic acid species include zirconium chloride (ZrCl4) and phosphonic acid (H3PO3), which manifest a ratio of exo:endo regioselectivity of about 5.0≠.3:1and about 4.00.3:1, respectively. |
| priorityDate |
2013-12-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |