http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3056221-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_825781254914b98449924c7493b3ab5d |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K51-082 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K51-065 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K51-088 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-13 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K103-10 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K51-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K51-08 |
| filingDate | 2016-01-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9322303482b2222bf37295affccc3a82 |
| publicationDate | 2016-08-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-3056221-A1 |
| titleOfInvention | Spect radionuclide-labeled trimeric cyclic rgd peptide, preparation method thereof and imaging method thereof |
| abstract | The disclosure is related to a chemical structure, a preparation and an imaging method of a tumor imaging tracer, especially to a SPECT radionuclide-labeled trimeric cyclic RGD peptide: 99m Tc-4P-RGD 3 , which functions as a ligand to be combined with integiin α v β 3 receptor in tumor for tumor imaging. The preparation includes linking HYNIC-OSu with 4P-RGD 3 to form HYNIC-4P-RGD 3 and then chelating HYNIC with 99m Tc to create 99m Tc-4P-RGD 3 . Animal biodistribution and imaging experiments reveal higher uptake in tumor and lower uptake in normal organs, therefore the disclosure can improve image quality. Through animal metabolic experiments, the original form of 99m Tc-4P-RGD 3 can be still excreted without the evidence of further metabolites in urine and feces. According to the disclosure, the tumor imaging tracer 99m Tc-4P-RGD 3 combined with the integrin αvβ3 solves the issue of high background uptake in normal organs, such that radio-labeled SPECT imaging tracers are more suitable for animal whole-body tumor evaluation. |
| priorityDate | 2015-02-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 83.