http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3031929-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5f41eeec5e75f79dedbdd6d2639e1b73 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-1003 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G16B20-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G16B20-40 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G16B20-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68 |
| filingDate | 2014-12-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_25219aa753287b900e678ca434a4ff2a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_219efe99f4553076ce0f3853336feda2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1cfa8a97586bad56f34a03ab9db157bf http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a1960d610566f0d8925df65d1d158cd8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_89858ef2ee4496422e21d2436a602ccf |
| publicationDate | 2016-06-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-3031929-A1 |
| titleOfInvention | Genome architecture mapping |
| abstract | The present invention relates to the field of analysis of the three-dimensional structure of the genome, i.e., for genome architecture mapping (GAM). The invention provides a method of determining spatial proximity of a plurality of nucleic acid loci in a compartment such as the cell nucleus, by exploiting their co-segregation amongst fractions of that compartment, identified upon separation of the nucleic acid loci from each other depending on their localization in the compartment to obtain a collection of fractions, e.g., by cryo-sectioning the compartment; determining the presence or absence of the plurality of loci in said fractions; and determining the co-segregation of said plurality of loci. Co-segregation may then be analysed with statistical methods to determine spatial proximity. The method can be used e.g., for determining physical distance between a plurality of loci; and mapping loci and/or genome architecture, e.g., in the nucleus; identification of regulatory regions directing expression of a specific gene through spatial contacts; identifying the nuclear position of an exogenous nucleic acid in the nucleus and/or diagnosing a disease associated with a disturbed co-segregation of loci. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2021215927-A1 |
| priorityDate | 2014-12-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 24.