http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3027626-A1
Outgoing Links
Predicate | Object |
---|---|
assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_277c3695533f5075b05990f25f65462f |
classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D498-22 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D498-22 |
filingDate | 2014-08-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8d109acdb81b62c919ad3341b0eb9d4a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_41b52a1c81582dd47710afc014e4f2c0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f8b11008a825a9f2b487c88a4d76fc19 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8b127525d007442de228ef74663c413c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_da49fd0207c4a44ad4b595f1fa6ab23f |
publicationDate | 2016-06-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | EP-3027626-A1 |
titleOfInvention | A process for preparing rifaximin k |
abstract | The present invention relates to a process for obtaining rifaximin κ comprising the following steps:a) reacting rifamycin O with 2-amino-4-picoline in the presence of a solvent mixture comprising water and a solvent selected from methyl isobutylketone, ethylacetate and a water soluble solvent; b) obtaining a rifaximin solution by removing the aqueous phase; c) obtaining rifaximin κ from the rifaximin solution, wherein when the solvent is a water soluble solvent, either methyl isobutylketone or ethylacetate is further added in step a). In another aspect the process of the invention relates to a process for obtaining the crystalline form κ of rifaximin comprising the following steps: i) contacting rifaximin or a rifaximin solution with exclusively ethylacetate, ii) obtaining the rifaximin in crystalline form κ by removing ethylacetate. |
priorityDate | 2013-08-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 58.