| abstract |
The object of the invention is 3,4-dihydroisoquinoline derivative of structure represented by formula I, wherein R 1 is selected from the group consisting of H, COOEt, COOH, COOBn; R 2 is selected from the group consisting of H, COOEt, COOH, COOBn; R 3 is selected from the group consisting of OH, OBn; R 4 is selected from the group consisting of OH, H, OBn; R s is selected from the group consisting of OH, OBn; and isomers, salts, hydrates and solvates thereof, as well as the method of preparation thereof; pharmaceutical composition comprising the above mentioned derivative and use thereof. |