| abstract |
The invention relates to compounds characterized by a general formula (1), wherein X is a group described by a general formula -Kp-Fr Kq-, wherein - Fl is -C(=0)-,-C(=S)-, with I being 0 or 1, - Kp is a Cp-alkyl with p being 0, 1, 2, 3 or 4, - Kq is a Cq -alkyl with q being 0, 1, 2, 3 or 4, and wherein n of R1 n is 0, 1, 2, 3, 4 or 5, and each R1 independently from any other R1 is -C(=O)OR2, -C(=O)NR2 2, -C(=O)SR2, -C(=S)OR2, -C(NH)NR2 2, CN4H2, -NR2 2, -C(=O)R2, -C(=S)R2, -OR2, -SR2, -CF3, -OCF3, -SCF3, -SOCF3, -SO2CF3, -CN, -NO2, -F, -CI, -Br or -I, with each R2 independently from any other R2 being a hydrogen or C1-C4 alkyl, and wherein OM is an organometallic compound independently selected from the group of an unsubstituted or substituted metal sandwich compound, an unsubstituted or substituted half metal sandwich compound or a metal carbonyl compound and their use in a method for treatment of infections by helminths. |