| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_fab5a78161702097f97524ce6e5cdcd7 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2800-042
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2800-044
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-531
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-11
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-141 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-4702
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-6893
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-713
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-113
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-1135 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-11
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-113
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-574 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-713
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-01
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-705 |
| filingDate |
2014-09-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_85dca591aa047c700a1788034cc2d33c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c2ade9811d584ff9edaf53f99581224f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_78cbf8f4f6361206b8bb0a1ce27af0f2
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ddf0123ee4f0ba1bd7d6a11896d15baa |
| publicationDate |
2016-03-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-2998396-A1 |
| titleOfInvention |
Manipulation of hairy and enhancer of split 3 (Hes3) and its regulators/mediators in diabetes, obesity, and metabolic syndrome |
| abstract |
The present invention relates to an inhibitor of Hairy and Enhancer of Split 3 (Hes3) for use in a method of preventing or treating (i) a disease characterised by insulin resistance or (ii) obesity. Further, the present invention also relates to a method of preventing or treating a disease characterised by insulin resistance or obesity, to a pharmaceutical composition comprising Hes3 and to Hes3 and/or an activator thereof for use in a method of preventing or treating a disease characterised by decreased insulin production. In addition, the present invention relates to a method of preventing or treating a disease characterised by decreased insulin production and to the use of Hes3 as a target in a screen for identifying a compound suitable as a lead compound and/or as a medicament for the treatment of diseases characterised by insulin resistance or of obesity or of diseases characterised by decreased insulin production. Moreover, the present invention relates to in-vitro or ex-vivo methods for identifying a compound suitable as a lead compound and/or as a medicament for the treatment and/or prevention of diseases characterised by insulin resistance or of obesity or of diseases characterised by decreased insulin production. Finally, the present invention also relates to an in-vitro method of eliciting or enhancing insulin production. |
| priorityDate |
2014-09-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |