http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2998394-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7da5c8e8c3e8261efe7e698c7198681b |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y207-07049 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-1276 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P19-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6869 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-12 |
| filingDate | 2014-05-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7d6234406f494c78f4b2f94501008d38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_278164f9a6af3b9dd0e3dcb53a4ad494 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_896d5c99e8972d8d4c92e926218a291b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f80b88a4468b6d120f9c8c1b018659dd |
| publicationDate | 2016-03-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-2998394-A1 |
| titleOfInvention | Hiv type 1 group o reverse transcriptases that are active at high temperatures |
| abstract | The present invention falls within the field of biotechnology. More specifically, the invention relates to reverse transcriptases expressed and purified in bacteria and having the amino acid sequence of the reverse transcriptase of a human immunodeficiency virus type 1 (HIV-1) group O, modified at positions 358, 359 and 360; and variants of this enzyme that contain additional changes at positions 355 and 357 or at 478 or position 69 (in this case accompanied by an insertion of two amino acids). These polymerases have greater activity than the non-mutated enzyme at high temperatures (above 60 C). In addition, they retain the capacity for DNA synthesis at temperatures greater than 70 C. Moreover, the copying fidelity of these enzymes is not significantly different from that of the non-mutated reverse transcriptase |
| priorityDate | 2013-05-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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