| abstract |
The present invention relates to naphthyl sulfonamide phenyl derivatives of the formula In nin which R1, R2, R3, R4, R5, R6, R7, R8, R10, A, X, L, q, i and R50 are defined as indicated below. n The naphthyl sulfonamide phenyl derivatives I are KEAP-1 modulators and useful for the prevention and/or treatment of diabetes, obesity, dyslipidemia and related disorders. The invention furthermore relates to the use of naphthyl sulfonamide phenyl derivatives of the formula I as active ingredients in pharmaceuticals, and pharmaceutical compositions comprising them. |