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filingDate 2014-09-15-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationDate 2016-03-16-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber EP-2995934-A1
titleOfInvention Improved nanopore plasmonic analyser
abstract An apparatus for investigating a molecule is provided. It includes: n• a chip comprising (a) a substrate perforated with at least one nanopore and (b) at least one pair of nanostructures juxtaposed about the nanopore thereby defining a gap in which an electromagnetic field can be generated by localised surface plasmon resonance; n• first and second chambers arranged either side of the chip and linked by the nanopore(s); n• a source of incident electromagnetic radiation for inducing localised surface plasmon resonance in the nanostructures: n• a controller for causing molecules to pass from the first to the second chambers via the nanopore(s) and through the electromagnetic field and n• a detector for detecting Raman-scattered radiation produced by the molecules as they pass through the electromagnetic field. n The apparatus is characterised in that the gap between the nanostructures in each pair is less than 10 nanometres and that each pair of nanostructures has been prepared by coating a pair of precursor nanostructures that are separated by greater than or equal to 10 nanometres. The apparatus is suitable for sequencing nucleic acids and proteins.
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