abstract |
The purpose of the present invention is to provide a novel monoclonal antibody having high affinity and that strictly recognizes, as a sugar chain epitope, only a "Sia±2,6Gal²1,4GlcNAc (6'-Sialyl-LacNAc): CDw75" sugar chain structure, being a molecular target for diagnosis of the malignancy of tumors. An anti-CDw75 monoclonal antibody is provided that recognizes "CDw75" sugar chain structures but does not recognize similar sugar chain structures indicated by "Gal²1,4GlcNAc", "Sia±2,3Gal²1,4GlcNAc", or "Sia±2,6Gal²1,4Glc", by using a glycolipid antigen bonding a carrier lipid compound "HOCH 2 CH (NH-CO- (CH 2 ) 22 -CH 3 ) - (CH 2 ) 9 -CH 3 (C12L) " developed by the inventors to a "CDw75" sugar chain. The obtained anti-CDw75 monoclonal antibody is an excellent detection drug for B-cell lymphoma, gastric cancer, or colorectal cancer, an excellent diagnostic agent for tumor malignancy, etc., an excellent treatment agent for B-cell lymphoma, gastric cancer, or colorectal cancer, and an excellent prevention/treatment drug for influenza. |