| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_26b94b520c4bc0d178adc4e9548b84f1 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P5-32
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P15-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J1-007
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J1-0074
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0019
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J31-006
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-565 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-565
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J31-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P5-32 |
| filingDate |
2013-04-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b71f14df959f7399434fbd13fcd7ba21
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_030923ca7f24481e9f9ba5e2c8006e54
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ae58dc9a0c4ddf23152d43b23c8ceec0 |
| publicationDate |
2016-02-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-2987799-A1 |
| titleOfInvention |
Ester derivative of 7-alpha-[9-(4,4,5,5,5-pentafluoropentylsulphinyl)nonyl]oestra-1,3,5(10)-triene-3,17beta-diol having antitumour activity and preparation method thereof |
| abstract |
The present invention provides a class of fulvestrant ester derivatives and preparation method thereof. Such a compound is an aliphatic ester formed by esterifying the -OH at positions C-3 and C-17 of fulvestrant, having a structure of the following formula: In the formula, substituent R is H, alkanoyl or alkenoyl having 2 to 22 carbon atoms or stereoisomers thereof; substituent R' can be H, alkanoyl or alkenoyl having 2 to 4 carbon atoms or stereoisomers thereof; such an aliphatic ester compound being used as a pro-drug can improve the stability of a compound, meanwhile the decrease of polarity can enable them to be easily made into preparations like lipid emulsion, microsphere etc., and avoid the degradation of the compound caused by factors like high temperature etc. and the use of an organic solution during preparation process. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2987492-A4 |
| priorityDate |
2013-04-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |