abstract |
The present invention is directed to Buprenorphine Analog compounds of Formula (I), (II) or (III) and including various stereoisomers (such as Formula (IA) shown below), wherein R 1 , R 3a , R 3b , R 16 , R 15 , G, Q, X, and Z are as defined herein. Compounds of the Invention are useful for treating pain, constipation, and other conditions modulated by activity of opioid and ORL-1 receptors. |