| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3bcefc58df9a9b010fba8789569389ee |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6869
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6844
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-1252 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-48 |
| filingDate |
2009-03-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6e28ce679cde14080464982a291a83d0
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bf9d0ada570fce06fe3e9af434971003
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_139d6daf90f5cbf77dbe061805251fa7
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d9b2fdf84a6ca62b1ba723ddbb6c598a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b76c6981bb5290efb30fc21cb14b152a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8a651be346992458456679830f210597
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bcad4d5e7c9b57a7a486cc1357ac0338
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_614d7c43fd2e0dd4f74990cfe28c6b2c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d1635265fe05e27354402c4a145b7e82
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_75b1333796d7d0dad107176c5acd4fe3 |
| publicationDate |
2015-11-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-2942404-A1 |
| titleOfInvention |
Generation of modified polymerases for improved accuracy in single molecule sequencing |
| abstract |
Provided are compositions comprising modified recombinant polymerases that exhibit branching fractions that are less than the branching fractions of the polymerases from which they were derived, or branching fractions that are less than about 25% for a phosphate-labeled nucleotide analog. Also provided are compositions comprising modified recombinant polymerases that exhibit closed polymerase/DNA complexes with increased stability relative to the parental polymerase. Also provided are compositions comprising modified recombinant polymerases that exhibit decreased rate constants relative to the parental polymerases. Provided are methods for generating polymerases with the aforementioned phenotypes. Provided are methods of using such polymerases to make a DNA or to sequence a DNA template. |
| priorityDate |
2008-03-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |