| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4d1b37af041ed385e56d2002106bf108 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-76
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2318-20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-1793 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-2866
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-7155
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-02 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-17
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-715 |
| filingDate |
2013-10-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_108f736d7cb860a7a27d80aa6734cd02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_82110a1eb90a5160344a7d8ed701baff
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6104e9d6413e9e2074b12d34ae6655b8
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ff777ed6d00e0a2fec3332dceda8f04d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ea166868fb044fc9f8ad1924f68afb8a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_41d8ab77dcd6143187fb61053bf19cae |
| publicationDate |
2015-09-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-2922560-A1 |
| titleOfInvention |
Polypeptide antagonists of human il-23 receptor for treatment of autoimmune diseases |
| abstract |
The present invention provides a novel class of polypeptides (REX binders), derived from an albumin-binding domain of the streptococcal protein G that inhibit binding of human IL-23 cytokine to its cognate IL-23 receptor. Blocking of interaction between p19/IL-23 subunit with the receptor leads to the suppresion of IL-23-dependent pro-inflammatory signaling pathway, resulting in an inhibitory effect on IL-23-stimulated Th-17 cell expansion. The invention further provides a DNA sequence encoding for such polypeptides and host cells containing such sequence. The polypeptides of the invention are useful as therapeutics and diagnostics.˙ |
| priorityDate |
2012-11-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |