| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_00a421ab71bd49a451d0a49d23a082c7
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8528ff66470c896b6da8ed059464e31f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ce3d57a6fc2fad533ce367f648d280ec |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-76
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-24 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-3076
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-191
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-39558
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-2863 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-501 |
| filingDate |
2013-09-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b9f7825ff7fac0c2f979a4c11a81dfdb
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b92a4ffa98dc24c4c9b5c038196ef4b6 |
| publicationDate |
2015-07-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-2890383-A2 |
| titleOfInvention |
Modulating transendothelial migration and recruitment of granulocytes by modulating c-met pathway |
| abstract |
The present application relates to granulocytes and their role in both cancer and inflammation. More particularly, it was found that c-Met expressed by granulocytes is important in transmigration and recruitment of the granulocytes. It is shown that reducing c-Met-mediated transmigration of granulocytes sustains tumor progression, indicating that c-Met-mediated granulocyte transmigration should actually be maintained because it is beneficial in treatment of cancers, particularly cancers that otherwise show resistance to c-Met inhibition. Reducing c-Met-mediated transmigration on the other hand is particularly useful in conditions characterized by an excessive immune response, such as asthma. |
| priorityDate |
2012-08-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |