| abstract |
The present invention is based, in part, on the discovery of isolated nucleic acid molecules encoding mutant RAC polypeptides, or a fragments thereof, wherein the mutant RAC polypeptides comprise one or more substitutions of an amino acid in the wild-type RAC polypeptide that renders the mutant RAC polypeptides constitutively active and oncogenic. Isolated mutant RAC polypeptides encoded by such nucleic acid molecules, as well as vectors, host cells, methods of producing encoded polypeptides using such isolated nucleic acid molecules, as well as methods of using mutant RAC nucleic acids and polypeptides for identifying, assessing, prognosing, and treating cancer, are also provided. |