Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_08a3a6ad3f21ac5177a32576c7f88c7a |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-192 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-60 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-48 |
filingDate |
2013-04-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_77b780c01ac00f25c47b0d2f06cee64f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f1d893ffb3c06069710c6ec0460f0135 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_eb3c2bac09f92d8be94e21469ede8249 |
publicationDate |
2015-03-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
EP-2841109-A1 |
titleOfInvention |
Prodrugs of hydroxyl-comprising drugs |
abstract |
The present invention relates to a prodrug or a pharmaceutically acceptable salt thereof comprising a biologically active moiety-linker conjugate D-L, wherein D is a hydroxyl-comprising biologically active moiety; and L is a promoiety comprising a moiety L1 represented by formula (I) and wherein L1 is substituted with one to four groups L2-Z and optionally further substituted, provided that the hydrogen marked with the asterisk in formula (I) is not replaced by a substituent; wherein L2 is a single chemical bond or a spacer and Z is a carrier group. The invention also relates to pharmaceutical compositions comprising said prodrugs and their use as medicaments. |
isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10464877-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10752605-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10053414-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9845305-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11339139-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9776982-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10450290-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9643911-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10759733-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10344012-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11034645-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9957220-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10464878-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11046666-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10703706-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10988435-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11505535-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10246403-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11407707-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9701616-B2 |
priorityDate |
2012-04-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |