| abstract |
Methods and compositions are provided for treating weight related conditions and metabolic disorders by altering microbiota in a subject. One aspect provides methods and compositions to alter microbiota in a subject by administering to the subject a composition that includes a substantially purified microbiota from phyla such as Bacteroidetes, n Proteobacteria, Firmicutes and Verrucomicrobia or orders such as Bacteroidales, n Verrucomicrobiales, Clostridiales and Enterobacteriales or genera such as Alistipes, n Clostridium, Escherichia, and Akkermansia . Another aspect includes a pharmaceutical composition for altering microbiota that includes a therapeutically effective amount of substantially purified microbiota and a pharmaceutically acceptable carrier. Yet another aspect includes methods for treating a disorder, such as obesity, in a subject in need of such treatment by substantially increasing or decreasing a relative abundance of microbiota in a gastrointestinal tract of the subject without or in addition to a surgical procedure. Also provided are methods of altering microbiota in a subject by administering a composition to the subject thereby altering a microbiota in the subject so that the microbiota mimics a microbiota found in a subject responsive to a gastric bypass or other gastrointestinal bariatric or metabolic procedure. Methods and compositions of altering a relative abundance of microbiota to alter metabolic function and of altering a relative abundance of short chain fatty acids to alter metabolic function are also provided. |