http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2820145-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ec0024795f45a646ef64b3664ab8a26d http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ce7c542a5a6dc02c10fc2e0a619c4186 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2800-046 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2800-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2458-15 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2326-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2800-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-904 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-57407 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-32 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-00 |
| filingDate | 2013-03-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0de2d403a7b966bfb5fb2b4d0141477f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_05fdbdda34ce8ec3633fe1f6a1d02b4d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_069436e6a60a839e4c2ec20f31d6aeab http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e0d5becc2739f4814338d07465774d69 |
| publicationDate | 2015-01-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-2820145-A1 |
| titleOfInvention | Means and methods for the determination of (d)-2-hydroxyglutarate (d2hg) or (d)-2-hydroxyadipic acid |
| abstract | The present invention relates to a method for detecting (D)-2-hydroxyglutarate or (D)-2- hydroxyadipic acid in a sample, the method comprising the steps of: a) contacting a sample with a reagent mixture, wherein said reagent mixture comprises: (i) a solvent, (ii) a dye having an oxidized state and a reduced state, wherein the reduced state can be distinguished from the oxidized state and wherein the dye is initially present in the oxidized state,(iii)an electron transfer agent, (iv)a (D)-2-hydroxyglutarate dehydrogenase enzyme, and (v) a cofactor; and b) detecting (D)-2-hydroxyglutarate or (D)-2- hydroxyadipic acid by measuring the production of the reduced state of the dye. The invention further pertains to a method for diagnosing and/or monitoring a (D)-2-hydroxy- glutarate-associated disease in a subject. Encompassed by the invention is also a method for diagnosing a mutation in an isocitrate dehydrogenase (IDH) gene or in a (D)-2- hydroxyglutarate (D2HG) dehydrogenase enzyme gene in a subject. In addition, the invention provides for a kit comprising (i) a solvent, (ii) a dye having an oxidized state and a reduced state, wherein the reduced state can be distinguished from the oxidized state and wherein the dye is initially present in the oxidized state,(iii)an electron transfer agent, (iv)a (D)-2-hydroxyglutarate dehydrogenase enzyme, and (v) a cofactor. |
| priorityDate | 2012-03-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 123.