http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2816117-A3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6b0b7cf96a504f75c44b1c2b82ed56e2 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02A40-146 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-8257 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-78 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-8273 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-415 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-82 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-78 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01H5-00 |
| filingDate | 2005-09-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_377ecbb5eebb0d8021576adb3cc8e34a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e2f9a70c50351ebd36d31ab661b985c8 |
| publicationDate | 2015-05-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-2816117-A3 |
| titleOfInvention | Collagen producing plants and methods of generating and using same |
| abstract | The present invention relates to a type I collagen which comprises a C-terminus and/or N-terminus propeptide, obtainable by expressing in a plant or isolated plant cell a type I collagen alpha chain including a signal peptide for targeting to a vacuole and being devoid of an ER retention sequence, a mammalian lysyl hydroxylase 3 (LH3), and a human prolyl 4 hydroxylase (P4H) including a signal peptide for targeting to a vacuole and being devoid of an ER retention sequence, and accumulating said type I collagen alpha chain, said LH3 and said P4H in a vacuole of the plant or the isolated plant cell. The present invention further relates to a method of producing fibrillar collagen in a plant or an isolated plant cell comprising: (a) targeting to and accumulating in a vacuole of the plant or the isolated plant cell a collagen alpha I chain including a signal peptide for targeting to a vacuole and being devoid of an ER retention sequence, a collagen alpha II chain including a signal peptide for targeting to a vacuole and being devoid of an ER retention sequence, and an exogenous human prolyl 4 hydroxylase (P4H) including a signal peptide for targeting to a vacuole and being devoid of an ER retention sequence, said collagen alpha I chain, said collagen alpha II chain and said human prolyl 4 hydroxylase (P4H) being expressed in said plant or isolated plant cell; and (b) harvesting said plant or plant cell and isolating the collagen. |
| priorityDate | 2004-09-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 48.