| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_cf32b60391b469c41e86c353437f5751 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4725
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-10 |
| filingDate |
2012-12-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0df5c881aef98a4477533e11982d9520
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a3e1a0106b8602fa0b53dabf6136a732
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a94b0865bb9dfdca29aa7c52de6a0a7a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6325af931d6087264206369f285c834c |
| publicationDate |
2014-10-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-2794591-A1 |
| titleOfInvention |
Compounds for inhibiting the interaction of bcl2 with binding partners |
| abstract |
The present invention relates to compounds of formula I: in which R 1 , R 2 , R 3 and R 4 are as defined in the Summary of the Invention. Compounds of formula I are capable of disrupting the BCL-2 interations with proteins containing a BH3 domain. Disrupting this interaction can restore the anti-apoptotic function of BCL-2 in cancer cells and tumor tissue expressing BCL-2. The invention further provides a process for the preparation of compounds of the invention, pharmaceutical preparations comprising such compounds and methods of using such compounds in the treatment of cancerous diseases. |
| priorityDate |
2011-12-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |