| abstract |
Benzimidazoles of formula (I): wherein: A is 5-to 12-membered aryl or 5-to 12-membered heteroaryl, each of which is unsubstituted or substituted; Y is a single bond, -(CH 2 ) p -, -X-, -CH 2 -X-, or -X-CH 2 -; X is -O-, -S-, -N(R 2 )-, >C=O, >S(=O), >S(=O) 2 , -O-C(=O)-, -C(=O)-O-, N(R 2 )-C(=O)-, or -C(=O)-N(R 2 )-; each L is independently a single bond, C 1-3 alkylene, C 2-3 alkenylene or C 2-3 alkynylene; R 1 is C 1-6 alkyl, C 2-6 alkenyl or C 2-6 alkynyl, each of which is unsubstituted or substituted; each Z is independently -N(R 2 ) 2 , -OR 2 , -SR 2 , -S(=O)R 2 , -S(=O) 2 R 2 ; each R 2 is independently hydrogen, C 1-6 alkyl, C 2-6 alkenyl or C 2-6 alkynyl, wherein said alkyl, alkenyl and alkynyl groups are unsubstituted or substituted; m is 0, 1, 2, or 3; n is 1, 2, or 3; and p is 1, 2, or 3; and the pharmaceutically acceptable salt thereof are inhibitors of RSV and can therefore be used to treat or prevent an RSV infection. |