http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2763977-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_966a6c1f382ec9bcb5e3839dfd73e5b8 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-506 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4439 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-04 |
| filingDate | 2012-10-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_77b9fa7336517d5916393661f1e6b3e8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4f7920b13c87bcdc8242fc19bdf4358b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9701f2b556166da3c1efb0bd877d12d8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d78e03cc1e994a21bd7dace1921ad8ff http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_96380533047fda258d7bb38577d963ae http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_db25eaec2b018021208e3d834d76fa52 |
| publicationDate | 2014-08-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-2763977-A1 |
| titleOfInvention | Ethynyl derivatives as mglur5 allosteric modulators |
| abstract | The present invention relates to ethynyl derivatives of formula (I) wherein U is N or CH, R 8 is hydrogen, halogen, lower alkyl or lower alkoxy;Y is –N(R 4 )-, -O- or –C(R 5 R 5 ')-; wherein R4 is hydrogen or lower alkyl and R 5 /R 5' are independently hydrogen, hydroxy, lower alkyl or lower alkoxy; V is –N(R 6 )- or –C(R 7 R 7' ), wherein R6 is hydrogen or lower alkyl and R 7 /R 7' are independently from each other hydrogen, lower alkyl, CH 2 -lower alkoxy or may form together with the carbon atom to which they are attached a C 3 -C 6 -cycloalkyl; R 1 is phenyl or heteroaryl, which are optionally substituted by halogen, lower alkyl or lower alkoxy; m is 0 or 1; in case m is 1, R 3 /R 3' are independently from each other hydrogen, lower alkyl, CH 2 -lower alkoxy or may form together with the carbon atom to which they are attached a C 3 -C 6 -cycloalkyl; n is 0 or 1; in case n is 1, R 2 /R 2' are independently from each other hydrogen, lower alkyl, CH 2 -lower alkoxy or may form together with the carbon atom to which they are attached a C 3 -C 6 -cycloalkyl; or if m is 1 and n is 0, R 3 and R 7 may form together with the carbon atoms to which they are attached a C 4-6 -cycloalkyl; or if m is 1 and n is 1, R 2 and R 3 or R 3 and R 7 may form together with the carbon atoms to which they are attached a C 4-6 -cycloalkyl; or to a pharmaceutically acceptable acid addition salt, to a racemic mixture, or to its corresponding enantiomer and/or optical isomer and/or stereoisomer thereof. It has been found that the compounds of general formula (I) are allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5). |
| priorityDate | 2011-10-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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