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publicationDate 2014-07-23-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber EP-2757155-A1
titleOfInvention Novel recombinant bcg vaccine
abstract Provided is a vaccine against tuberculosis in which the active ingredient is a recombinant BCG bacterium capable of promoting cytokine production. Preparing recombinant BCG bacterium (rBCG-SOCS1dn) incorporating a vector for expressing the SOCS1 dominant negative variant (a mutation of 1 amino acid), which is an antagonist that acts antagonistically against SOCS1 function, provides a recombinant BCG bacterium capable of promoting cytokine production. This recombinant BCG bacterium secretes the SOCS1 dominant negative variant protein extracellularly.
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