Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_81ad53b64eb74859acdc01278829b080 |
classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-9121 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-542 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5041 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5011 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-57492 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-542 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-50 |
filingDate |
2012-08-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_66cc87061487cab00ae1de196919a322 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_78eec8aedb2d2d62f95bd9cb63f0b4f1 |
publicationDate |
2014-07-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
EP-2751562-A1 |
titleOfInvention |
Profiling of signal pathway proteins to determine therapeutic efficacy |
abstract |
The present invention provides methods for detecting, measuring and quantitating the activation states of components of the PI3K signaling pathway in cells such as tumor cells and selecting an anticancer therapy therewith. The methods involve a collaborative enzyme enhanced reactive-immunoassay (CEER) in which first activation state-independent antibodies specific for one member of a dimerised receptor tyrosine kinase (RTK) pair or a PI3K p110 subunit are labeled with a facilitating moiety (e.g. glucose oxidase) and second activation state-independent or dependent antibodies specific for the other member of the RTK pair or PI3K p85 or PI3K p110 subunit labeled with a signal amplification moiety (e.g. HRP). |
isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9688761-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10273304-B2 |
priorityDate |
2011-09-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |