abstract |
The present invention relates to novel benzodiazepinone compounds of Formulae (I) wherein R 1 , R 2 , R 4 , R 6 , R 7 , R 8 , R 9 , and R 10 are as defined herein. The invention also relates to pharmaceutical compositions containing such compounds, methods of use of such compounds and compositions, and methods for preparing the compounds and compositions. The compounds are Group II metabotropic glutamate antagonists or allosteric modulators and are useful for the treatment of a variety of CNS disorders. |