| abstract |
The present invention relates to a compound of general formula (I) below: R 1 -NH-CH (R 2 ) -P (= O) (OR 3 ) -CH 2 -C (R 4 ) (R 5 ) -CONH-CH (R 6 ) -COOR 7 (I) or a pharmaceutically acceptable salt thereof, an isomer or a mixture of isomers in all proportions, especially a mixture of enantiomers, and in particular a racemic mixture, for which R 1 represents a group -C (= O) -OC (R 8 ) (R 9 ) -OC (= O) -R 10 ; R 2 represents an optionally substituted hydrocarbon chain, an aryl or heteroaryl group or a methylene group substituted by a heterocycle; R 3 represents a hydrogen atom or a group-C (R 12 ) (R 13 ) -OC (= O) -R 14 ; R 4 and R 5 together with the carbon which carries them form a saturated hydrocarbon ring or an optionally substituted piperidine ring or R 4 represents a hydrogen atom and R 5 represents an optionally substituted phenyl or benzyl, a heteroaromatic ring or a methylene group substituted by a heterocycle; R 6 represents an optionally substituted hydrocarbon chain or an optionally substituted phenyl or benzyl; and R 7 represents a hydrogen atom or a benzyl, alkyl, heteroaryl, alkylheteroaryl, -CHMe-COOR 18 , -CHR 19 -OC (= O) R 20 and -CHR 19 -OC (= O) OR 20 group .n n n The present invention also relates to the combination of these compounds with another analgesic, their use as a medicament, and in particular for the treatment of pain, more preferably neuropathic and neuroinflammatory pain, their synthesis process as well as the compositions thereof. container. |