| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_37f4922dfb7777b019e504b885211b8e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_42f352cc5bd193c17ffff15bf60e16f7 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6929
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6923
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-108
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K41-0052
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-60
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-0065 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K41-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-48 |
| filingDate |
2012-12-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate |
2014-06-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-2740491-A1 |
| titleOfInvention |
Conjugates of the B-subunit of shiga toxin for use as contrasting agents for imaging and therapy |
| abstract |
Multivalent conjugates comprising the following formula: (STxB-linker A-S) x -GNS-(S-linker B-T) y wherein STxB is the B-subunit of Shiga toxin; linker A is a noncleavable linker; linker B is a cleavable linker used to release at least one T or a noncleavable linker; GNS is a gold nanostructure; S is a sulfhydryl group and x and y can vary from 1 to 8,000; and T is a molecule selected from the group of: contrast agents, cytotoxic agents, prodrugs and antigens and x and y can vary from 1 to 10,000. These multivalent conjugates can be used in therapy to treat cancer and in medical imaging. Methods to distinguish normal cells from abnormal cells and methods for treating cancer by photothermal therapy or photothermal therapy and cytotoxic therapy are also part of the present invention. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111558040-B
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3058956-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111558040-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112341445-B
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2016134838-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105434446-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105434446-B
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112341445-A |
| priorityDate |
2012-12-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |