| abstract |
The invention relates to cis-tetrahydro-spiro (cyclohexane-1,1'-pyrido [3,4-b] indole) -4-amine derivatives for use in the treatment of neuropathic and / or chronic pain due to nociceptin / ORL-1 receptor system and act on the μ-opioid receptor system and are characterized in particular by a selective efficacy in the treatment of chronic pain (including inflammatory pain, visceral pain, tumor pain, preferably neuropathic pain), without pronounced efficacy in acute to develop nociceptive pain. |