| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1a48b04f986c44c2ca9129ce0b1d17c6 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-26
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-19
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-455
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-10 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-19
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-455
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-26
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-10 |
| filingDate |
2012-06-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0f9da61fa2db5fd6834645f591329821
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8745072baaccc9c9ff75e7815e14cb62
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f76cc6b3149080d6a42d281c69a4f1ae |
| publicationDate |
2014-05-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-2727593-A1 |
| titleOfInvention |
Nicorandil-containing pharmaceutical composition |
| abstract |
Provided is a pharmaceutical composition comprising nicorandil, mannitol, and an alkali metal salt of an organic carboxylic acid, wherein (1) the ratio of "a value of an X-ray diffraction peak of δ-form crystals of the mannitol at 9.8° ± 0.3° (2θ)"/"a value of an X-ray diffraction peak of nicorandil crystals at 10.6° ± 0.3° (2θ)" is 2.0 or less, or (2) the ratio of "an intensity of a peak of δ-form crystals of the mannitol at 1.01 THz ± 0.2 THz in a second derivative spectrum of an absorption spectrum obtained by terahertz transmission spectroscopy"/"an intensity of a peak of nicorandil crystals at 0.95 THz ± 0.2 THz in the second derivative spectrum of the absorption spectrum obtained by the terahertz transmission spectroscopy" is 1.5 or less. This pharmaceutical composition is excellent in storage stability. |
| priorityDate |
2011-06-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |