http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2721178-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3e035457406455ea05989c01cb90c8f1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3bf194612e66a0e282c600ce65a626c1 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-118 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-158 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6886 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-57415 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68 |
| filingDate | 2012-06-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d232bf3f9f69d282e1ce01888ecd238b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_46d77bf0d727f4bfa590c9cc5ff0a10f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ec64062c93b95db34371830e45d4286e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b3356619a479e825ed7e8f64e7bd0d51 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_803201e8b4069f0fc25173d2778cd737 |
| publicationDate | 2014-04-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-2721178-A1 |
| titleOfInvention | Method for the prognosis of breast cancer based on the expression of the gene pin1 in combination with mutations in the gene tp53 |
| abstract | It is described the influence of the presence of mutations in the TP53 gene in association with high levels of the enzyme prolyl isomerase Pin1 and a molecular signature of 10 genes expression correlated with the expression of Pin1 and p53 for the prognosis of breast tumors. The association between overexpression of Pin1 and the presence of protein p53 mutants induces transcriptional programs which promote tumor aggressiveness and in a cohort of patients the overexpression of Pin1 has proved to influence the prognostic value of the presence of mutations in the gene TP53. The assessment of the expression of Pin1 in the presence of mutations of the gene TP53, together with the detection of the expression of the genes forming the molecular signature can therefore be used for the prognosis of breast cancer. |
| priorityDate | 2011-06-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 335.