| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4de98e14ea5db1a33a6958a10893a477 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C2601-16 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C51-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C403-20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C51-353 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C51-353
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C403-20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C59-64 |
| filingDate |
2012-05-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fc309f1bdc1642ebdddbe5a499d2da80
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e04daf18d4e3acac31ab23b6c4e4179b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e024958f7e6473d0de54bfa6f57659fb
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a522fdbbc9c9db0384751a3b16607257
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2c1d2f3c30c12b4a78015cf08f33a5bd |
| publicationDate |
2014-03-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-2708530-A1 |
| titleOfInvention |
Stereospecific synthesis process for tretinoin compounds |
| abstract |
A stereospecific synthesis process for tretinoin compounds comprises the following steps: using substituted triphenyl phosphine salt and β-formyl crotonic acid as raw material to carry out WITTIG reaction under the action of alkali; then adjusting the pH of the reaction liquid to 5-10; adding palladium compound or rhodium compound to carry out isomerization directly and obtain tretinoin compounds with desired configuration. The product yield of the process is high and the intermediate product in the reaction dose not need to be separated. The process is easy to operate and can save the production cost and as well is suitable for industrial production. |
| priorityDate |
2011-05-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |