| abstract |
The present invention provides a compound of formula (I):n nwherein n-X= is -CR 7 = or -N=, nring B is a substituted or unsubstituted carbocycle or a substituted or unsubstituted heterocycle, nR 1 is substituted or unsubstituted alkyl or the like, nR 2a and R 2b are each independently hydrogen, substituted or unsubstituted alkyl or the like, nR 3 and R 4 are each independently hydrogen, halogen, substituted or unsubstituted alkyl or the like, nR 5 is hydrogen, substituted or unsubstituted alkyl or the like, neach R 6 is independently halogen, hydroxy, substituted or unsubstituted alkyl or the like, R 7 is hydrogen, halogen, hydroxy, substituted or unsubstituted alkyl or the like, np is an integer of 0 to 3, nor a pharmaceutically acceptable salt thereof which has an effect of inhibiting amyloid β production, especially an effect of inhibiting BACE1, and which is useful as a therapeutic or prophylactic agent for diseases induced by production, secretion and/or deposition of amyloid β proteins. |