| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_cacf06bc194abe6aab5626a9ab540e53
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2ac55092bbe1f4ae3b2e12454bbc62af |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-14 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-395
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-39591
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P21-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-395
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P21-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-00 |
| filingDate |
2012-04-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_00112baf48299b882fd4538c43827efa
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6f4a3043a1caf6e6238439050a75ae37
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_87440ec99557c770f8ea7180782c1cf5
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0c9ea6cc464ab574a8b9f9c33dc0db22
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9932843d928eaca93cec671d18de52f0
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_962dd84a54da82703ff54cc5e0aea5a9 |
| publicationDate |
2014-03-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-2702164-A1 |
| titleOfInvention |
A method for reducing heterogeneity of antibodies and a process of producing the antibodies thereof |
| abstract |
The present disclosure relates to a method of reducing heterogeneity in antibodies during culturing, wherein the heterogeneity is due to proportion of charge variant of the antibody. The disclosure also comprises a process of growing cells in a cell culture system that results in antibodies with the reduced heterogeneity. In one embodiment antibody heterogeneity is reduced by the addition of divalent transitional metal ions such as zinc (Zn 2+ ) to the cell culture medium. In another embodiment antibody heterogeneity is reduced by decreasing the osmolality of the cell culture medium. |
| priorityDate |
2011-04-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |